Tarbiat Modares University International Journal of Musculoskeletal Pain Prevention 2476-5279 Articles in Press 2026 03 14 Pain( Anatomy and Practical Tips): review article 28285 10.48311/ijmpp.2026.118428.82912 EN Monireh Motaqi Physiotherapy Research Center, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Ali Ghanjal Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Journal Article 2025 12 21 Aims: The aim of this review article is to briefly address the anatomy of pain, the concept of pain, and some related topics.<br>Method and Materials: This article was conducted by reviewing scientific articles related to pain (including the anatomy of pain, the concept of pain, types of pain, neural connections of pain, and other related topics).<br>Findings: Pain is an unpleasant sensation that usually occurs following physical and mental damage, and is one of the topics discussed in various sciences, including medicine and psychology. Pain is one of the body's protective mechanisms against stimuli and damage to it. Pain has been classified and defined in various ways in terms of intensity, type, cause, transmission pathways, and other side effects.The pain system (as a sensory system) includes primary afferents in the spinal cord to various areas of the brain. The experience of pain is modulated by interactions in its ascending and descending pathways. A proper understanding of these modulatory mechanisms is vital in health and disease and for treatment in various clinical conditions.<br>Conclusion: This study briefly refers to pain and its concept, the stages of pain perception, pain receptors and pathways, the modulatory effect of these pathways on pain reduction, types of pain, and some related issues.