Volume 1, Issue 1 (2016)                   IJMPP 2016, 1(1): 41-45 | Back to browse issues page

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1- MSc Student, Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
2- MD, Professor of Obstetrics and Gynecology, Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
3- PhD of Nuclear Medicine, Research Institute for Nuclear Medicine, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Abstract:   (9516 Views)
Background: we aimed to evaluate the effect of body weight and Body Mass Index (BMI) on Bone Mineral Density (BMD) in healthy postmenopausal Iranian women. Material and Methods: Two hundred postmenopausal women (age between 51 and 69 years) who had presented to the nuclear medicine center at Shariati Hospital in Tehran, Iran between April 2012 and August 2013 were included in this cross sectional study. Of these 46 healthy women who met the study criteria constituted for evaluation. After recording weight and height of individuals, Body Mass Index (BMI) (kg/m2) was calculated as weight (kg) divided by height square (m2). Bone Mineral Density (BMD) in Femoral Neck (FN) and lumbar spine sites (L1-L4) were measured by dual-energy X-ray absorptiometry (DEXA). Results: We observed statistically significant negative correlation between BMD measurements at femoral neck and lumbar1-4 spine with age and significant positive correlation with weight and BMI. Stepwise multiple linear regression analysis showed that only weight and age, after adjustments to BMI determined lumbar1-4 spine BMD (R² = 23%) and femoral neck BMD (R² = 28.6%). Conclusions: These results suggest that the relationship between body weights and BMD is Stronger than the relationship between BMI and BMD. Therefore, in comparison with body mass index, body weight alone is a better predictor of bone mineral density.
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Subject: Musculoskeletal Pain Prevention
Received: 2015/10/7 | Accepted: 2015/11/16 | Published: 2016/02/16

1. Baheiraei, A., Pocock, N. A., Eisman, J. A., Nguyen, N. D. & Nguyen, T. V. (2005) Bone mineral density, body mass index and cigarette smoking among Iranian women: implications for prevention. BioMed Center Musculoskelet Disorder.6 (34), 1-9. [DOI:10.1186/1471-2474-6-34]
2. Bener, A., Hammoudeh, M. & Zirie, M. (2005) Is obesity a protective factor for osteoporosis? International Journal of Rheumatic Diseases. 8 (1), 32-38. [DOI:10.1111/j.1479-8077.2005.00119.x]
3. Burge, R., Dawson-Hughes, B., Solomon, D. H., Wong, J. B., King, A. & Tosteson, A. (2007) Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. Journal of Bone and Mineral Research. 22 (3), 465-475. [DOI:10.1359/jbmr.061113]
4. Compston, J., Cooper, A., Cooper, C., Francis, R., Kanis, J. A., Marsh, D., et al. (2009) National Osteoporosis Guideline Guidelines for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK. Maturitas. 62 (2), 105-108. [DOI:10.1016/j.maturitas.2008.11.022]
5. De Laet, C., Kanis, J. A., Oden, A., Johanson, H., Johnell, O., Delmas, P., et al. (2005) Body mass index as a predictor of fracture risk: a meta-analysis. Osteoporosis International. 16 (11), 1330-1338. [DOI:10.1007/s00198-005-1863-y]
6. El Maghraoui, A., Guerboub, A., Mounach, A., Ghozlani, I., Nouijai, A., Ghazi, M., et al. (2007) Body mass index and gynecological factors as determinants of bone mass in healthy Moroccan women. Maturitas. 56 (4), 375-382. [DOI:10.1016/j.maturitas.2006.10.004]
7. Fried, L. P., Borhani, N. O., Enrigh, t. P., Furberg, C. D., Gardin, J. M., Kronmal, R. A., et al. (1991) The Cardiovascular Health Study: design and rationale. Annals of Epidemiology. 1 (3), 263-276. [DOI:10.1016/1047-2797(91)90005-W]
8. Genaro, P. S., Pereira, G. A., Pinheiro, M. M., Szejnfeld, V. & Martini, L. A. (2010) Influence of body composition on bone mass in postmenopausal osteoporotic women. Archives of Gerontology and Geriatrics. 51 (3), 295-298. [DOI:10.1016/j.archger.2009.12.006]
9. Gustafsson, A. & Lindenfors, P. (2009) Latitudinal patterns in human stature and sexual stature dimorphism. Annals of Human Biology. 36 (1), 74-87. [DOI:10.1080/03014460802570576]
10. Himes, J. H. (1988) Racial variation in physique and body composition. Canadian Journal of Sport Sciences. 13 (2), 117-126.
11. Jordan, K. M. & Cooper, C. (2002) Epidemiology of osteoporosis. Best Practice & Research Clinical Rheumatology. 16 (5), 795-806. [DOI:10.1053/berh.2002.0264]
12. Knoke, J. D. & Barrett-Connor, E. (2003) Weight loss: a determinant of hip bone loss in older men and women. The Rancho Bernardo Study. American Journal of Epidemiology. 158 (12), 1132-1138. [DOI:10.1093/aje/kwg265]
13. Malina, RM. (1973) Biological substrata. In: Miller KS, Dreger RM, eds. Comparative studies of blacks and whites in the United States. New York: Seminar Press. 53-121.
14. Malina, RM. (1996) Regional body composition: age, sex, and ethnic varia-tion. In: Roche AF, Heymsfield SB, Lohman TG, eds. Human body composition. Champaign, IL: Human Kinetics. 217-255.
15. Ooms, M. E., Lips, P., Van Lingen, A. & Valkenburg, H. A. (1993) Determinants of bone mineral density and risk factors for osteoporosis in healthy elderly women. Journal of Bone and Mineral Research. 8 (6), 669-675. [DOI:10.1002/jbmr.5650080604]
16. Pietschmann, P., Rauner, M., Sipos, W. & Kerschan-Schindl, K. (2009) Osteoporosis: an age-related and gender-specific disease-a mini-review. Gerontology. 55 (1), 3-12. [DOI:10.1159/000166209]
17. Reginster, J. Y. & Burlet, N. (2006) Osteoporosis: a still increasing prevalence. Bone. 38 (2), 4-9. [DOI:10.1016/j.bone.2005.11.024]
18. Rensch, B. (1938) Some problems of geographical variation and species-formation. Proceedings of the Linnean Society of London. 150 (4), 275-285. [DOI:10.1111/j.1095-8312.1938.tb00182k.x]
19. Robbins, J., A. Schott, M., Azari R. & Kronmal, R. (2006) Body mass index is not a good predictor of bone density: results from WHI, CHS, and EPIDOS. Journal of Clinical Densitometry. 9 (3), 329-234. [DOI:10.1016/j.jocd.2006.02.005]
20. Rosen, C. J. & Bouxsein, M. L. (2006) Mechanisms of disease: is osteoporosis the obesity of bone? Nature Reviews Rheumatology. 2 (1), 35-43. [DOI:10.1038/ncprheum0070]
21. Ruff, CB. (2002) Variation in human body size and shape. Annual Review of Anthropology 31, 211-232. [DOI:10.1146/annurev.anthro.31.040402.085407]
22. Schott, A. M., Cormier, C., Hans, D., Favier, F., Hausherr, E., Dargent-Molina, P., et al. (1998) How hip and whole-body bone mineral density predict hip fracture in elderly women: the EPIDOS Prospective Study. Osteoporosis International. 8 (3), 247-254. [DOI:10.1007/s001980050061]
23. Srivastava, M. & Deal, C. (2002) Osteoporosis in elderly: prevention and treatment. Clinics in Geriatric Medicine journal. 18 (3), 529-555. [DOI:10.1016/S0749-0690(02)00022-8]
24. Tuck, S. P. & Francis, R. M. (2002) Osteoporosis. Postgraduate Medical Journal. 78 (923), 526-532. [DOI:10.1136/pmj.78.923.526]
25. Zhao, L., Jiang JH., Papasian, C. J., Maulik, D., Drees, B., Hamilton, J. & Deng, H. W. (2008) Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis. Journal of Bone and Mineral Research. 23 (1), 17-29. [DOI:10.1359/jbmr.070813]

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