Volume 6, Issue 1 (2021)                   IJMPP 2021, 6(1): 451-459 | Back to browse issues page

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1- Department of Sport Sciences, Shiraz University, Shiraz, Iran.
2- Department of Sport Sciences, Shiraz University, Shiraz, Iran. , koushkie53@yahoo.com
Abstract:   (1727 Views)
Aim: This study aimed to  investigate the effect of two weeks of vitamin D3 supplementation on some indices of Delayed Onset of Muscle Soreness (DOMS) after  eccentric exercise.
Method and Materials: In this semi experimental study, 20 nonathletic male collegiate students (19.75±1.29 years) participated in the study voluntarily and were divided randomly into two groups of experimental (n=11) and placebo (n=9). The experimental group consumed vitamin D3 (Cholecalciferol) containing 50000 IU while the placebo group took apparently similar capsules containing starch like, two capsules for two weeks. To induce DOMS, participants performed a step protocol that included four sets (5 minutes for each set), with a 1-minute of rest interval between each set using a 46 cm-step. Range of Motion (ROM) of low extremity joints and circumferences, and Visual Analog Scale (VAS were measured before, immediately after (Time 0), and 24 hours (Time 1) and 48 hours (Time 2) after eccentric exercises.
Findings: This study showed that thigh Thigh circumference increased following eccentric exercise in the placebo group, while it did not change significantly in the experimental group (p>0.05). There was no significant difference between the two study groups regarding other variables (P>0.05). Vitamin D3 supplementation with the dosage and duration used in the present study reduced the limited symptoms of DOMS. Future studies of longer duration or higher dosage of vitamin D supplementation are recommended.  
Conclusions: According to the finding of this study, vitamin D3 supplementation could not reduce the limited symptoms significantly. However, future studies are suggested to evaluate the effect of higher dose or longer duration of vitamin D supplementation on DOMS.
Full-Text [PDF 399 kb]   (473 Downloads)    
Article Type: Original Research | Subject: Sport Sciences, Therapy and Medicine
Received: 2021/01/26 | Accepted: 2021/02/5 | Published: 2021/03/12

1. Clarkson PM, Hubal MJ. Exercise-Induced Muscle Damage in Humans. Am J Phys Med Rehabil. 2002,81:S52-S69. [DOI:10.1097/00002060-200211001-00007]
2. Connolly DA, Sayers SP, McHugh MP. Treatment and prevention of delayed onset muscle soreness. J Strength Cond Res. 2003,17:197-208. [DOI:10.1519/00124278-200302000-00030]
3. Udani JK, Singh BB, Singh VJ, Sandoval E. BounceBack™ capsules for reduction of DOMS after eccentric exercise: a randomized, doubleblind, placebo-controlled, crossover pilot study. J Int Soc Sports Nutr. 2009,6:14. [DOI:10.1186/1550-2783-6-14]
4. Cheung K, Hume PA, Maxwell L. Delayed onset muscle soreness. Sports Med. 2003,33:145-164. [DOI:10.2165/00007256-200333020-00005]
5. Lieber RL, Friden J. Morphologic and mechanical basis of delayed-onset muscle soreness. J Am Acad Orthop Surg. 2002;10(1):67-73. [DOI:10.5435/00124635-200201000-00009]
6. Kim J, Lee J. A review of nutritional intervention on delayed onset muscle soreness. Part I. J Exerc Rehabil. 2014,10:349-356. [DOI:10.12965/jer.140179]
7. Sellwood KL, Brukner P, Williams D, Nicol A, Hinman R. Ice-water immersion and delayedonset muscle soreness: a randomised controlled trial. Br J Sports Med. 2007,41:392-397. [DOI:10.1136/bjsm.2006.033985]
8. Nosaka K, Sakamoto K. Effect of elbow joint angle on the magnitude of muscle damage to the elbow flexors. Med Sci Sports Exerc. 2001,33:22-29. [DOI:10.1097/00005768-200101000-00005]
9. Herbert RD, de Noronha M, Kamper SJ. Stretching to prevent or reduce muscle soreness after exercise. Cochrane Database Syst Rev. 2011. [DOI:10.1002/14651858.CD004577.pub3]
10. Hollmann W, Strüder HK. Sportmedizin: Grundlagen für körperliche Aktivität, Training und Präventivmedizin; mit 91 Tabellen: Schattauer Verlag; 2009.
11. Bakhtiary AH, Safavi-Farokhi Z, Aminian-Far A. Influence of vibration on delayed onset of muscle soreness following eccentric exercise. Br J Sports Med. 2007,41:145-148. [DOI:10.1136/bjsm.2006.031278]
12. Curtis D, Fallows S, Morris M, McMakin C. The efficacy of frequency specific microcurrent therapy on delayed onset muscle soreness. J Bodyw Mov Ther. 2010,14:272-279. [DOI:10.1016/j.jbmt.2010.01.009]
13. Lavender AP, Nosaka K. A light load eccentric exercise confers protection against a subsequent bout of more demanding eccentric exercise. J Sci Med Sport. 2008,11:291-298. [DOI:10.1016/j.jsams.2007.03.005]
14. Tartibian B, Maleki BH, Abbasi A. The effects of ingestion of omega-3 fatty acids on perceived pain and external symptoms of delayed onset muscle soreness in untrained men. Clin J Sport Med. 2009,19:115-119. [DOI:10.1097/JSM.0b013e31819b51b3]
15. Cooke MB, Rybalka E, Williams AD, Cribb PJ, Hayes A. Creatine supplementation enhances muscle force recovery after eccentrically-induced muscle damage in healthy individuals. J Int Soc Sports Nutr. 2009,6:13. [DOI:10.1186/1550-2783-6-13]
16. Giamberardino M, Dragani L, Valente R, Di Lisa F, Saggin R, Vecchiet L. Effects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effort. Int J Sports Med. 1996,17:320-324. [DOI:10.1055/s-2007-972854]
17. Kaminski M, Boal R. An effect of ascorbic acid on delayed-onset muscle soreness. Pain 1992,50:317-321. [DOI:10.1016/0304-3959(92)90037-C]
18. Etheridge T, Philp A, Watt PW. A single protein meal increases recovery of muscle function following an acute eccentric exercise bout. Appl Physiol Nutr Metab. 2008,33:483-488. [DOI:10.1139/H08-028]
19. Bischoff-Ferrari HA, Dietrich T, Orav EJ, Hu FB, Zhang Y, Karlson EW, et al. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged ≥60 y. Am J Clin Nutr. 2004,80:752-758. [DOI:10.1093/ajcn/80.3.752]
20. Barker T, Schneider ED, Dixon BM, Henriksen VT, Weaver LK. Supplemental vitamin D enhances the recovery in peak isometric force shortly after intense exercise. Nutr Metab (Lond). 2013,10:69. [DOI:10.1186/1743-7075-10-69]
21. Garcia LA, King KK, Ferrini MG, Norris KC, Artaza JN. 1,25(OH)2Vitamin D3 Stimulates Myogenic Differentiation by Inhibiting Cell Proliferation and Modulating the Expression of Promyogenic Growth Factors and Myostatin in C2C12 Skeletal Muscle Cells. Endocrinol. 2011,152:2976-2986. [DOI:10.1210/en.2011-0159]
22. Willis KS, Smith DT, Broughton KS, LarsonMeyer DE. Vitamin D status and biomarkers of inflammation in runners. Open Access J Sports Med. 2012,3:35-42. [DOI:10.2147/OAJSM.S31022]
23. Carrillo AE, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, et al. Vitamin D supplementation during exercise training does not alter inflammatory biomarkers in overweight and obese subjects. Eur J Appl Physiol. 2012,112:3045-3052. [DOI:10.1007/s00421-011-2279-3]
24. Clarkson PM, Hoffman EP, Zambraski E, GordishDressman H, Kearns A, Hubal M, et al. ACTN3 and MLCK genotype associations with exertional muscle damage. J Appl Physiol. 2005,99:564-569. [DOI:10.1152/japplphysiol.00130.2005]
25. Bryer S, Goldfarb AH. Effect of high dose vitamin C supplementation on muscle soreness, damage, function, and oxidative stress to eccentric exercise. Int J Sport Nutr Exerc Metab2006,16:270-280. [DOI:10.1123/ijsnem.16.3.270]
26. Lenn J, Uhl T, Mattacola C, Boissonneault G, Yates J, Ibrahim W, Bruckner G., et al. The effects of fish oil and isoflavones on delayed onset muscle soreness. Med Sci Sports Exerc. 2002,34:1605- 1613. [DOI:10.1097/00005768-200210000-00012]
27. Stone MB, Merrick MA, Ingersoll CD, Edwards JE. Preliminary comparison of bromelain and ibuprofen for delayed onset muscle soreness management. Clin J Sport Med. 2002,12:373-378. [DOI:10.1097/00042752-200211000-00009]
28. Tokmakidis SP, Kokkinidis EA, Smilios I, Douda H. The effects of ibuprofen on delayed muscle soreness and muscular performance after eccentric exercise. J Strength Cond Res. 2003,17:53-59. [DOI:10.1519/00124278-200302000-00009]
29. Barlas P, Craig JA, Robinson J, Walsh DM, Baxter GD, Allen JM. Managing delayed-onset muscle soreness: lack of effect of selected oral systemic analgesics. Arch Phys Med Rehabil. 2000,81:966- 972. [DOI:10.1053/apmr.2000.6277]
30. Meamarbashi A, Abasian M. The effect of ten days of cinnamon consumption on biochemical and functional indicators on DOMS. Sport Physiol. 2013,20:63-80. [DOI:10.1093/oseo/instance.00096429]
31. Tanabe Y, Chino K, Ohnishi T, Ozawa H, Sagayama H, Maeda S, et al. Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation. Scand J Med Sci Sports. 2019,29:524-534. [DOI:10.1111/sms.13373]
32. Gulick DT, Kimura IF, Sitler M, Paolone A, Kelly IV JD. Various treatment techniques on signs and symptoms of delayed onset muscle soreness. J Athlet Train. 1996,31:145.
33. Chleboun GS, Howell JN, Conatser RR, Giesey JJ. Relationship between muscle swelling and stiffness after eccentric exercise. Med Sci Sports Exerc. 1998,30:529-535. [DOI:10.1097/00005768-199804000-00010]
34. Bendik I, Friedel A, Roos FF, Weber P, Eggersdorfer M. Vitamin D: a critical and essential micronutrient for human health. Front Physiol. 2014,5. [DOI:10.3389/fphys.2014.00248]
35. Beaudart C, Buckinx F, Rabenda V, Gillain S, Cavalier E, Slomian J, et al. The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: a systematic review and metaanalysis of randomized controlled trials. J Clin Endocrinol Metab. 2014,99:4336-4345. [DOI:10.1210/jc.2014-1742]
36. Nosaka K, Newton M. Concentric or eccentric training effect on eccentric exercise-induced muscle damage. Med Sci Sports Exerc. 2002,34:63- 69. [DOI:10.1097/00005768-200201000-00011]
37. Jouris KB, McDaniel JL, Weiss EP. The effect of omega-3 fatty acid supplementation on the inflammatory response to eccentric strength exercise. J Sports Sci Med. 2011,10:432.
38. Tartibian B, Maleki BH, Abbasi A. Omega-3 fatty acids supplementation attenuates inflammatory markers after eccentric exercise in untrained men. Clin J Sport Med. 2011,21:131-137. [DOI:10.1097/JSM.0b013e31820f8c2f]
39. Lembke P, Capodice J, Hebert K, Swenson T. Influence of omega-3 (n3) index on performance and wellbeing in young adults after heavy eccentric exercise. J Sports Sci Med. 2014,13:151.
40. Gray P, Chappell A, Jenkinson AM, Thies F, Gray SR. Fish oil supplementation reduces markers of oxidative stress but not muscle soreness after eccentric exercise. Int J Sport Nutr Exerc Metab. 2014,24:206-214. [DOI:10.1123/ijsnem.2013-0081]
41. Nieman DC, Gillitt ND, Shanely RA, Dew D, Meaney MP, Luo B. Vitamin D2 Supplementation Amplifies Eccentric Exercise-Induced Muscle Damage in NASCAR Pit Crew Athletes. Nutrients 2014,6:63-75. [DOI:10.3390/nu6010063]
42. Peterson JM, Trappe TA, Mylona E, White F, Lambert CP, Evans WJ, et al. Ibuprofen and acetaminophen: effect on muscle inflammation after eccentric exercise. Med Sci Sports Exerc.2003,35:892-896. [DOI:10.1249/01.MSS.0000069917.51742.98]
43. Beck TW, Housh TJ, Johnson GO, Schmidt RJ. Effects of a protease supplement on eccentric exercise-induced markers of delayed-onset muscle soreness and muscle damage. J Strength Cond Res. 2007,21:661. [DOI:10.1519/R-21016.1]
44. Choi M, Park H, Cho S, Lee M. Vitamin D3 supplementation modulates inflammatory responses from the muscle damage induced by high-intensity exercise in SD rats. Cytokine. 2013,63:27-35. [DOI:10.1016/j.cyto.2013.03.018]
45. Ke C-Y, Yang F-L, Wu W-T, Chung C-H, Lee R-P, Yang W-T, et al. Vitamin D3 reduces tissue damage and oxidative stress caused by exhaustive exercise. Int J Med Sci. 2016,13:147. [DOI:10.7150/ijms.13746]

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