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Volume 0, Issue 0 (Articles accepted at the time of publication 2024)
Abstract

Over the past decades, empirical studies regarding the application of data-driven learning (DDL) and its’ role in second and foreign language learning have increased. At the same time, several studies have investigated the association between working memory (WM) and different aspects of L2 and found that WM plays a significant role in the language performance of L2 learners, as SLA processes rely on cognitive resources. Nevertheless, the findings of such research are inconclusive. The role of WM in the relationship between DDL and second/foreign language learning is also a neglected area. Drawing on data from 84 Iranian female EFL learners, aged between 20 to 24, on three different measures of WM capacity (digit span, number-letter, and flanker), the findings of the present study showed that first, DDL was a significant predictor of English academic lecture comprehension. Second, regardless of which WM measure to use, WM was not a significant predictor of English academic lecture comprehension; and the interaction effect between DDL and WM was not a significant predictor of the students’ English academic lecture comprehension. That is, WM did not moderate the effect of DDL on the students’ comprehension of English academic lectures. Altogether, the results suggested that learning L2 at high levels of English academic lecture comprehension was mostly contingent upon automatic processing. The findings of this study may have implications for research and practice in second/foreign language teaching and learning, and more specifically in the application of DDL for L2 learners. 
Seyedeh Somayeh Kazemi, Mohammad Rafighi,
Volume 1, Issue 4 (10-2016)
Abstract

Background: Musculoskeletal disorders are one of difficulties in communities that has negative effect on various aspect of life. The aim of this study was to evaluate musculoskeletal disorders in students.
Materials and methods: In this study cross-sectional descriptive-analytic approach, 306 college students were enrolled by using nonprobability purposive sampling method and also availability. Data was obtained based on demographic data questionnaire and musculoskeletal researcher-made questionnaire. After collecting required data, SPSS software version 19 was used for descriptive and statistical analysis.
Results: According to the obtained results and symptoms associated with musculoskeletal pains, it should be noted that 93 cases suffered from low back pain (30.4%), 76 cases from knee pain (24.8%), 50 cases from shoulder pain (16.3%), 21 cases from heel pain (9.6%), 65 cases from neck pain (21.3%), 10 cases from pelvic pain (3.3%), 50 cases from wrist pain (16.3%), and 6 cases from elbow pain (2%).
Conclusion: The study showed that most students were suffering from musculoskeletal problems in the lower back, knees and neck. Therefore providing correct and sufficient training for the students while doing their daily activities could be of great help in the prevention and control of the musculoskeletal problems in the students.

Volume 3, Issue 4 (12-2017)
Abstract

Background: Enterobious vermicularis (E. vermicularis) is one the most common parasitic infection among children.
Objectives: The present study aimed to determine the prevalence rate of enterobiasis among preschool children in Mazandaran province, northern Iran.
Materials and Methods: In this cross–sectional study, 653 preschool children were recruited via the cluster sampling method during April 2013 to Feb 2014. A questionnaire was administrated to parents by an interviewer and determined children’s socio-demographic characteristics, personal hygiene, and healthy behaviors. The Graham technique was applied for diagnosis. Data were analyzed using logistic regression model and chi-square test.
Results: In a total of 653 examined subjects, the prevalence rate of E. vermicularis was 19.4%, among which 40.9% were male, and 59.1% were female.  The highest and lowest prevalence rates of E. vermicularis were found in Neka (61.4%) and Tonekabon (1.6%) districts, respectively. A significant association was found between infection and residency, parental occupations, parental education, number of family members, changing underwear, sterilization of linen clothing, taking daily bath, boiling or ironing clothes.
Conclusions: The high prevalence rate of E. vermicularis infection in this study proves the stability status of enterobiasis in this area, posing a risk for children there. Systematic control of infection in children is proposed.
Seyedeh-Somayeh Kazemi, Reza Maghbouli, Mohammad Rafighi,
Volume 5, Issue 2 (Spring 2020)
Abstract

Aims: To determine the effects of the in-person interventions in employees suffering from Low Back Pain (LBP).
Method and Instruments: A quasi-experimental methodological design was utilized for this study. Participants were employees with LBP who participated in the Back School program workshop. The demographic questionaire, Visual Analog Scales (VAS), and behavior questionnaires were filled at baseline and 2 -onths follow up. The data were entered into SPSS and analyzed through the paired T-Test.
Findings: Thirty-one participants (27 males, 4 females) completed this survey. The study participants’ mean age was 40 ± 9.04 years. The intervention led to a decrease in the LBP scores of the employees (P< 0.0001) and improving behavior related to LBP.
Conclusion: This program can be suitable for the reduction of pain and improving behavior related to low back health among employees in the workplace.

Zahra Mohammadi, Rozina Rahnama, Roya Nikbakht, Parisa Hosseini-Koukamari,
Volume 5, Issue 3 (summer 2020)
Abstract

Aims: Recently, there has been an increasing attention in workplace health-related issues. The issue of MusculoSkeletal Disorders (MSDs) has obtained considerable critical attention. In this regard,work station has a pivotal role in prevention of MSDs. This study was conducted to assess Work-Related Musculoskeletal Disorders (WMSDs) among a sample of Iranian computer users.
Method and Instruments: A cross-sectional study was conducted on office computer users of a university in Tehran. The sample size of 435 people were randomly selected from the university employees. A standardized questionnaire was used to collect data. The data were analyzed using Spss.
Findings: The results revealed that the pain was frequently felt in the region of neck (64.4%), shoulder (60.9%) and wrist complaints (52.4%). The current study showed a high prevalence of MSDs among computer users. In addition, according to workstation questions, it was reported that there were no support device in for supporting lower back and arm in the workstation equipments.
Conclusion: Workstation is one of the essential factors for the prevention of occupational damages in MSDs. This study recommends that there is a need to investigate office equipments as a crucial element not only for promoting performance abalities, health, safety, and efficiency improving but also in reducing complaints and pain caused by MSDs.

Rahman Panahi, Seyedeh Somayeh Kazemi, Mohammad Rafighi,
Volume 5, Issue 3 (summer 2020)
Abstract

Aims: Service staff workers are important forces in hospitals.Hospitals are the best places to provide preventive and promoting health services. Due to the importance of Quality QOLLife (QOL)and the impact of Low Back Pain (LBP) on the QOLQOL of this target group, this study was conducted to assess the QOL and behaviors related to low back health among service staff at Shariati Hospital, Tehran, Iran.
Method and Instruments: In this cross-sectional descriptive study, 30 service staff workers were selected through simple random sampling. To evaluate the QOL and behavioral variables of individual , a demographic questionnaire, and the Short-Form Health Survey (SF-36) were used. To analyze the data, descriptive statistics were used.
Findings: In all 30 subjects in cluding 9 male (30%) and 21 female (70%)were studied. Of all participants, 10% (n=25) were single, and 83% (n= 25).were married. The results showed that service staff workers sometimes engage in back health-related behaviors. The mean scores of the dimensions of QOLQOL were as follows: Physical F±unctioning 69.66 ±27.9, Role Physical 75 ±32.8, Bodily Pain 60.16 ±24.0, General Health 58.43 ±19.9, Vitality 61.66±19.4, Social Functioning 64.16 ±26.4, Role Emotional 73.33 ±35.4 and Mental Health 65.06 ±19.25.
Conclusion: Despite doing health-related behaviors and moderate QOLQOL, designing proper educational interventions to improving the behaviors related-low back health and QOLQOL is strongly recommended.


Volume 5, Issue 4 (Fall 2019)
Abstract

Aims: Influenza A virus subtype H1N1, known as H1N1 influenza virus, could cause moderate to severe swine influenza in humans. H1N1 influenza is associated with high mortality rate. Effective symptom management could significantly reduce the mortality rate. This study aimed to determine the clinical manifestations, outcomes, and predictors of mortality in patients with H1N1 influenza, admitted to hospitals during January to September 2016.
Materials & Methods: This retrospective descriptive-analytical study was conducted during January to September 2016 in eight hospitals located in Razavi Khorasan province, northeastern Iran. The medical records of 65 patients were retrieved, and the necessary data were extracted from the records using a demographic questionnaire and a clinical manifestations checklist. The SPSS software Version 23.0 was used to analyze the data via the measures of descriptive statistics and the logistic regression analysis with odds ratio.
findings: The most common clinical manifestations of H1N1 influenza were headache (70.8%), numbness in the extremities (63.1%), myalgia (60%), cough (58.5%), fever and shivering (53.8%), and nausea (53.8%). In total, 14 (21.53%) patients had died due to H1N1 influenza. The significant predictors of death were dyspnea (OR: 13.91, p: .032), myalgia (OR: 0.04. p: .010), and age (OR: 1.05, p: .024) so that dyspnea and myalgia were associated with 13.9 and 0.04 times higher odds of death, respectively. Moreover, each one year increase in age was associated with 5% increase in the odds of experiencing death.
Conclusions: In the case of H1N1 influenza epidemics, care services need to be allocated more to patients who have higher age and suffer from myalgia and dyspnea.

 

Volume 6, Issue 2 (No.2 (Tome 23), (Articles in Persian) 2015)
Abstract

Physicians are more presumptuous than patients in verbal interaction. This study was conducted to measure the ratio of physicians’ and patients’ presumptuousness, and the role of gender in order to find an appropriate model for doctor-patient interaction. One hundred and one interviews in Mazandaran Medical Sciences hospitals were studied by using Stiles coding system. The physicians were 10.4 times more presumptuous than the patients. The most presumptuousness in the physicians was in physical examination, and in the patients, it was in conclusion. The least presumptuousness in physicians and in patients was in history taking and in physical examination, respectively. There was a meaningful difference in presumptuousness between men and women in the patients (P<0.05), while there was no meaningful difference between men and women in the physicians. Among the patients, rustics, low educated ones, and the elders were more presumptuous. When the gender of physicians and patients was different, the presumptuousness increased; however, the presumptuousness decreased when the gender was the same. We can conclude that the physicians were much more presumptuous than the patients. Their presumptuousness varied from the most in physical examination to the least in the history taking, because the physicians received information during the history taking and they listened more. In physical examination, the patients were in a special situation, sometimes unrobed. It strongly affected the presumptuousness. Presumptuousness had a direct relation with social class. Social class was the main factor when there was a gender difference, and it increased the physicians’ presumptuousness. The Results showed that in the patients, politeness in lower class decreased the presumptuousness. Knowing these factors can help physicians and patients to have an appropriate outcome
Seyedeh-Somayeh Kazemi,
Volume 6, Issue 3 (Summer 2021)
Abstract

Social media, known as the “participative Internet”[1] encompass a broad set of Internet-based communications, tools, aids, and work through several mechanisms. Social media can provide a channel for social support and facilitate a sense of connectedness among individuals. These online tools let users share information that is consumer-centric and consumercontrolled, enabling anonymity or personal connection as preferred, and can be an inexpensive way to reach large audiences over great distances [2]. Research now shows that some online communications are effective at improving knowledge and understanding of specific health topics. As well, social media can successfully encourage health improvement and behavior change [2]. Some approaches appear to be more effective than others in addressing shortor long-term goals. Evidence about social media’s impact on health knowledge, behavior, and outcomes shows these instruments can be effective in meeting individual and population health needs. One of the issues that social media has been successful at is non-specific Low Back Pain (LBP) [3-5]. Low back pain is a common cause of disability and is ranked as the most burdensome health condition globally [6,7]. Self-management, including components on increased knowledge, monitoring of symptoms, and physical activity, are consistently recommended in clinical guidelines as costeffective strategies for LBP management and there is increasing interest in the potential role of social media intervention. With the advancement of science and technology, education by traditional approach is a challenging way to provide information. It is recognized that traditional healthcare models have failed to significantly reduce care-seeking and costs associated with treatment. Conventionally, clinical management of LBP relies on face-to-face interactions between the healthcare provider and the patient. However, this approach is not affordable or accessible to a large number of individuals, particularly those living in remote locations. Social media is a tool for teaching about LBP that not only is accessible and well-received by participants but also has positive impacts on scores of knowledge and competency. Although some face-to-face orgroup session interventions to increase patient empowerment have been effective, but real opportunities for patient empowerment formed with the rise of the Internet and social media. The social media approach is more successful than the inperson intervention over the long term and might be a better way to present a program due to its ease of access and decreased implementation costs. The advantages of social media can mention access to education without time limitation, access to education without space limitation, remember and repeat the content, share information, access to a lot of educational content, low cost of education and use content over time. Therefore, the interventions for LBP (ie, patient education, behavior therapy, and exercise programs) could be delivered through one of the types of social media. Today, the number of Internet users has increased considerably, and the Internet is being employed more frequently to locate information on health and health care delivery. Social media such as telehealth, mobile-web, e-Health, etc. is a potential approach to deliver interventions for LBP patients aimed at improving individuals’ health status by providing education and services, reducing healthcare costs, and overcoming geographic barriers. Social media is an effective approach to reduce low back pain in a long time. As well, using the website where participants could access self-tailored strategies through their smartphones, is excellent and applicable. Therefore, a growing number of interventions aimed at patient empowerment are, not surprisingly, to be presented online.
Seyedeh Somayeh Kazemi, Rahman Panahi, Mohammad Rafighi,
Volume 6, Issue 4 (Fall 2021)
Abstract

Aims: Low Back Pain (LBP) is a major contributor to disability worldwide which affected the  Quality of Life (QOL). This study aimed to determine the correlation between pain intensity and QOL in patients with chronic LBP.
Method and Materials: In this study, 31 patients with LBP who referred to a pain clinic in Sari , the center city of Mazandaran province of Iran were selected through simple random sampling based on inclusion/exclusion criteria. Data collection was done using a demographic questionnaire, Visual Analog Scale (VAS), and Short Form Quality of Life (SF-36). To analyze the data, descriptive / analytical statistics were used through SPSS version 23.
Findings: Of the total number of patients, 51.62% were female (n=16), and 48.38% were male (n=15). The majority of the participants (N=22; 70.97%) aged greater than 60 years old. The result showed the majority of the participants (N= 17) of patients (54.85%) had  moderate pain. There was a significant correlation between pain intensity and all dimensions  of QOL except social functioning.
Conclusion: This study revealed that low back pain could decrease physical and mental functioning of the suffered patients. Although, doing more studies with larger sample and objective measurements, applying different approaches to decrease low back pain is guaranteed.   


Volume 7, Issue 1 (Winter 2019)
Abstract

Aims: Coronary artery bypass graft (CABG) with social isolation, treatment rejection, and negative perception of the health status of patients. One of the methods to detect these problems is evaluating the quality of life. This study aimed at determining the effect of self-care behavior education on quality of life of patients after CABG based on Pender’s health promotion model.
Materials & Methods: This semi-experimental was conducted on cardiac surgery candidates, who underwent CABG in the cardiac center hospital of Mazandaran, Iran in 2017. Subjects were selected and divided into two intervention and control groups, using block randomization. at 220 individuals (110 cases per group), and data were collected, using interviews with subjects, the self-care questionnaire based on Pender’s health promotion model in cardiac surgery candidates, and SF-36 quality of life questionnaire. Moreover, the patients were followed-up and trained for 3 and 6 months after the intervention.
Findings: In this research, ANOVA results demonstrated that the different structures of quality of life significantly changed at 3 periods, including before, 3, and 6 months after the intervention (p<0.001). Furthermore, the mean total score of quality of life was higher in the intervention group (56.244±1.474), compared to the control group (48.120±1.508) in all 3 periods.
Conclusion: According to the results of the study, it is recommended that the model designed and used in the current research be applied to perform healthcare behaviors, so that the quality of life of patients can be improved after cardiac surgery.
 


Volume 7, Issue 1 (Winter 2019)
Abstract

Aim: Breast cancer is the most common cancer in women.The Health Education Campaign (HEC) is an important educational strategy for breast cancer screening. The aim of this study was to investigate the effect of the (HEC) based training on the knowledge, attitudes, and practices of women, regarding breast cancer screening methods.
Materials & Methods: This was a pre- and post-quasi-experimental study conducted among 200 women over 20 years in Mazandaran Province. A self-made 34-item questionnaire was used to collect the data. A pretest was performed before the educational intervention and a posttest was conducted 12 weeks after the intervention. The data were analyzed by logistic regression, Pearson correlation coefficient, and one way ANOVA, using SPSS 22.
Findings: The mean age of the women was 35.16 years. Based on paired t-test, the difference in the mean scores of knowledge and attitudes regarding screening methods in the women was significant (p≤0.0001) before and after the intervention. Also, based on the macnemar test, the difference between the early detection of breast self-examination (BSE) and clinical breast examination (CBE) was significant in the women studied before and after the educational intervention.
Conclusion: According to the results of the study, the intervention had been able to change the knowledge, attitudes, and behaviors of women regarding breast cancer and early detection methods.
 
Sarallah Shojaei, Sedigheh-Sadat Tavafian, Ahmad Reza Jamshidi, Seyedeh Somayeh Kazemi,
Volume 7, Issue 1 (Winter 2022)
Abstract

Aim: Work - related Musculoskeletal Disorders (WMSds) are mainly associated with nurses’ high physical demands. Training healthy behavior can reduce these disorders. This study aimed to evaluate the effect of educational intervention based on Social Cognitive Theory (SCT) on changing unhealthy behaviors leading to(LBP) in nursing aid staff working in Qom hospitals.
Method and Materials: A quasi-experimental study was conducted from 2017 to 2018 with educational intervention based on SCT was performed on 452 nursing aid. Data collection tools were the questionnaire of SCT constructs, the LBP Prevention Behavior Questionnaire (LBPBPQ), the Quebec Back Pain Disability Scale (QBPDS), and the Visual Analog Scale (VAS) for LBP. The training was based on the four structures of self-efficacy, self-regulation, outcome expectation, and moral disengagement in groups of 20 to 30 individuals. Then the pre-and post-intervention data were compared through the statistical tests.
Findings: After the intervention, SCT structures were increased significantly. The mean score of lumbar health behavior after training showed a significant increase from 32.59 to 32.57. The mean score of LBP after training decreased significantly from 5.17 to 3.98 and the mean score of physical disability of LBP decreased significantly after training.
Conclusion: Educational intervention based on SCT reduces the severity of LBP and the consequent disability

Fatemeh Mohammadi Tavileh, Faramarz Gharagozlou, Seyedeh Somayeh Kazemi,
Volume 7, Issue 1 (Winter 2022)
Abstract

Aims: Telecommuting effects on various aspects of personal and professional life, such as productivity, work-life balance, performance, quality of life and job satisfaction. Due to limited knowledge regarding these impacts, the present study was conducted to review the 
evidences to conclude the overall effects of telework on personal and professional life of individuals who telework. 
Method and Materials: In this study key search was done between 2000 and 2021 in databases of science direct, web of science, pubMed, scopus, magiran and google scholar. Keywords were telecommuting, teleworking, productivity, job satisfaction, work-life balance, work- life conflict, stress and performance. 
Findings: This study showed telecommuting can have positive and negative effects on various aspects of personal and professional life, such as productivity, job satisfaction, work-life balance, and quality of work performance, work-life conflict and stress. Type of organization, community, family and the telecommuter himself  were various influential factors in this regard.
Conclusion: Due to the importance of the organizational productivity, family and community progress, and the telecommuter himself satisfaction, more attention should be paid to these  factors during Covid -19 prevalence. It is also recommended to conduct more studies on the effects of telecommuting on personal and professional life.

Fatemeh Mohammadi Tavileh, Faramarz Gharagozlou, Seyedeh Somayeh Kazemi,
Volume 7, Issue 4 (Fall 2022)
Abstract

Aims: Farmers are one of the high-risk occupational groups in terms of Work- related MusculoSkeletal Disorders (WMSDs). Many factors such as ddemographic and physical characteristics and lifestyle are effective in incidence of these disorders in farmers. The aim of this study is to investigating the prevalence of WMSDs and related factors among this target group.
Method and Materials: The data of this study was extracted from The Ravansar Non-Communicable Diseases (RaNCD) cohort study that was performed on 10,000 people aged 35 to 65 years in Ravansar, Iran. Version 23 of SPSS software was used for data analysis.
Findings: The prevalence of back pain in farmers was 31. 3%, back stiffness was 17.7%, joint pain was 37.3%, joint stiffness was 12.3% and spinal disorder was 22% included lordosis (15%) and kyphosis (7.3%). There was a significant relationship between gender, age and all disorders. There was no significant relationship between marital status, sleep status, alcohol consumption, Body Mass Index (BMI), weight and height, and any of the disorders. There was no significant relationship between education level, the type of residence, smoking and drug use, type of home ownership, internet use and some of disorders but there was a significant relationship between these factors and the other disorders. 
Conclusion: Considering the significant prevalence of WMSDs in farmers, it is necessary to perform ergonomic interventions in the form of occupational health training programs, in order to raising farmers’ awareness and skills to prevent the disorders. 

Marzieh Abedi, Seyedeh Somayeh Kazemi,
Volume 7, Issue 4 (Fall 2022)
Abstract

N/A

Volume 8, Issue 3 (Summer 2020)
Abstract

Aims: Epidemiological transition of acute and infectious diseases to non-communicable ones, aging population, together with rapid lifestyle changes all have given rise to prevalence rate of cardiovascular diseases (CVDs). Thus, it is of utmost importance to reflect on lifestyles, especially in this period. The main purpose of the present study was to assess lifestyle in patients affected with myocardial infarction (MI).
Instruments & Methods: This study was a cross-sectional study examining health-related lifestyle behaviors in patients with MI in 2019. To this end, a total number of 176 patients were selected using purposive and convenience sampling methods. The research instrument was also the Health-Promoting Lifestyle Profile II (HPLP-II) as a standardized self-report questionnaire. The data analyzed using IBM SPSS 22 and the generalized linear models were used. Moreover, coefficient at a significance level less than 0.05.
Findings: The results of Wilks’ lambda distribution revealed that the effect of gender on the linear combination of the dependent variable (i.e. lifestyle) was significant and 11.4% of changes in this variable had resulted from variation in gender. Besides, the results demonstrated that health responsibility scores in men were on average 2.703 lower than those obtained by women. This relationship was also significant and its effect size was by 3.3% (p= 0.016).
Conclusions: It was concluded that the concept of lifestyle can be an analysis tool to better understand differences between genders, as an effective variable in adopting a healthy lifestyle, especially in patients suffering from MI.


Volume 8, Issue 3 (Summer 2022)
Abstract

Backgrounds: Toxoplasma gondii is a zoonotic parasite of increasing concern to humans and animals. Considering the side effects of drugs used to treat toxoplasmosis, it is essential to find alternative drugs.
Materials & Methods: In this study, colchicine and propranolol at four concentrations (1, 5, 10, and 15 µg/mL) were added to the RPMI medium containing peritoneal macrophages and incubated for 60 min, Then tachyzoites were added to the medium, and the efficacy rates of colchicine and propranolol in inhibiting tachyzoites entry into macrophages were evaluated after 30 and 60 min. For in vivo assay, one group received no drugs, and the second group was treated with colchicine and propranolol at different concentrations for different durations.
Findings: The in vitro experiment showed that treatment with 15 mg/mL of colchicine and propranolol for 60 min following tachyzoites addition was the most efficient method to inhibit tachyzoites penetration, indicating the efficacy rates of 80.20%±1.20 and 89.97%±1.30, respectively (p< .05). Based on the in vivo test, pretreatment with 2 mg/kg of colchicine one hour before tachyzoites injection had the best inhibitory effect (70.32%±4.07). Also, pretreatment with 2 mg/kg of propranolol 90 min before tachyzoites injection (78.54%±1.99) induced the best inhibitory effect (p< .05).
Conclusion: According to the results, colchicine and propranolol could inhibit tachyzoites entrance into nucleated cells in vitro and in vivo. In this study, the most efficient concentrations and times for using these substances were determined.
 

Volume 9, Issue 2 (Spring 2018)
Abstract

Aims: Alchemilla L. genus (Rosaceae) has various biological activities such as anti-inflammatory, anticarcinogenic, antioxidant and antimicrobial. The aim of the present study was to investigate antioxidant activity and free radical scavenging of the extract obtained from Alchemilla persica by percolation, polyphenol fraction, and ultrasonic methods.
Materials and Methods: In the present experimental research, Alchemilla persica was used and percolation, polyphenol, and ultrasonics methods were used for extraction and the antioxidant activities of the extracts were determined by different tests, including 1, 1-Diphenyl-2-picrylhydrazyl (DPPH), nitric oxide scavenging activity, Iron chelating activity, and reducing power. Total phenolic and flavonoid content were measured by the Folin Ciocalteu and AlCl3 methods, respectively. The data were analyzed by SPSS 22 software, using one-way ANOVA and tukey test.
Findings: In DPPH radical scavenging activity, the polyphenol extract had a significant different with other extracts (p=0.001). Polyphenolic extract showed higher reducing power than other extacts and Vitamin C (p=0.001). Percolation extract had higher amounts of total phenolic and flavonoid content than other extracts.
Conclusion: Polyphenolic extracts have the highest DPPH, nitric oxide scavenging activity, Iron chelating activity, and reducing power compared to ultrasonic and percolation methods. Aerial parts of Alchemilla persica extracts have high levels of antioxidant activity including phenols and flavonoids.


Volume 9, Issue 2 (Spring 2023)
Abstract

Backgrounds: Several studies have elucidated vitamin D as an important immunomodulatory factor regulating immune responses to different viral infections and vaccines. This study aimed to evaluate the impact of 25(OH) D serum levels on immune responses to hepatitis B virus (HBV) vaccine.
Materials & Methods: This study was conducted on 134 healthy individuals aged 18-35 years, referring to health centers for HBV vaccination in Mane and Samalghan city in North Khorasan, Iran from June to September 2021. Demographic data were collected through a questionnaire. Serum 25(OH) D levels were analyzed using commercial sandwich ELISA kits. Anti-hepatitis B surface antibody (anti-HBsAb) levels were determined in blood samples 4-6 weeks post-vaccination.
Findings: The prevalence of vitamin D deficiency and insufficiency among the participants was 46.3 was 34.3%, respectively. The level of 25(OH) D was insignificantly higher in women than in men. There was no significant association between serum 25(OH) D levels and participants' ethnicities and BMI ranges. Anti-HBsAb titer was significantly higher in participants with sufficient vitamin D levels compared to those with insufficient and deficient levels (1835 ± 252.55 vs. 1129 ± 120.7 and 1363 ± 0.125 ng/ml). Serum anti-HBsAb levels post HBV vaccination were significantly higher in women and younger individuals than in men and older individuals, respectively.  
Conclusion: This study findings suggest that participants with different serum vitamin D levels produce seroprotective antibody titers post HBV vaccination, while those with sufficient vitamin D levels may produce higher titers against HBV vaccine.
 

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