The roles of osteoprotegerin in bone diseases: a brief review

Document Type : Systematic Review

Authors
masoumeh mohammadi
alireza jalali
Sport Medicine and Knee Research Center, Milad Hospital, Tehran, Iran.
10.48311/ijmpp.2025.110577.0
Abstract
Aim: This article aims to highlight the crucial role of Osteoprotegerin (OPG) in bone homeostasis and to propose it as a potential therapeutic target for common bone diseases.
Method and Materials: A literature review was conducted focusing on the structure, function, and regulatory effects of OPG on osteoclast activity, as well as its mechanism as a decoy receptor that inhibits osteoclast formation.
Findings: Evidence indicates that OPG plays a protective role against excessive bone loss by inhibiting osteoclast differentiation and activity. Its unique structure, consisting of a signal peptide and seven functional domains, enables it to act effectively in the extracellular space to maintain bone balance.
Conclusion: OPG is a key regulator of bone metabolism and may represent a promising therapeutic target for the treatment and prevention of bone-related disorders. Increased attention to this protein could lead to innovative therapeutic strategies in metabolic bone disease management.

 

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International Journal of Musculoskeletal Pain Prevention
Volume 10, Issue 3
October 2025
Pages 1246-1253